On their website, the club state that since 2009 they have been aware of plans to build a new residential tower block on the their doorstep but managed to reject the proposals nearly 2 years ago.
However London Mayor Boris Johnson has asked for the application to be reconsidered and will decide the fate of the club on 26th February.
So Ministry Of Sound are now asking for help from anyone looking to save the club by tweeting their reasons why it should be saved, using the hashtag #savemosclub
The tweets will then be gathered and shown to the Mayor before he makes a decision.
For more info, visit http://www.ministryofsound.com/savemosclub